Materials-Driven Strategies for Translational Bioelectrical Interfaces
The field of electronic and photonic biointerfaces is advancing rapidly, propelled by breakthroughs in materials science, biophysics, and physical chemistry. This interdisciplinary convergence has led to the design of bioelectronic systems with unprecedented multifunctionality, including the integration of living components. These systems are poised to revolutionize sensing, biological modulation, and regenerative medicine by addressing challenges at the interface of synthetic and biological materials. Our research focuses on the development of non-genetic bioelectronic platforms that exploit advanced materials design to achieve precise and scalable biological interactions across molecular, cellular, and tissue levels. Key achievements include the creation of optoelectronic systems for photostimulation based on nanoporous and non-porous heterojunctions. These materials provide enhanced control over charge transport and light-matter interactions, enabling highly targeted therapeutic interventions. Another significant focus is the seamless integration of living cells with hydrogels and wearable bioelectronics. By investigating dynamic material-biology interface formation and the principles of bioelectrical signaling, we have developed platforms that mimic and enhance natural biological processes. Future directions in our work aim to extend the capabilities of bioelectronic systems through the discovery of novel materials and interface designs. By bridging the gap between synthetic constructs and living systems, we seek to establish new paradigms in bioelectronic modulation and sensing, ultimately translating these innovations into clinical applications that advance human health and well-being.