QCB Seminar featuring Taekjip Ha: Biophysical Principles of Genome Organization Across Multiple Scales
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Join us in Beckman 3269 and on Zoom for Taekjip Ha, Please note the change of day and time: this is a Thursday at 11 a.m.!
Title: Biophysical Principles of Genome Organization Across Multiple Scales
Abstract:
Recent advances in genetics, biochemistry, cell biology, and biophysics have contributed to our understanding that the genome is organized hierarchically, with higher-order macromolecular assemblies spanning spatial and temporal orders of magnitude. Beyond being wrapped around histones as irregular groups of “beads on a string”, chromatin is organized into topologically associated domains, which are composed of small and large loops, and form euchromatic and heterochromatic compartments. In this talk, I will present biophysical principles we are uncovering about genome organization across three different scales, including sequence-dependent DNA mechanics [1], chromatin loops for homology search [2], and polyamines' role in translating nucleosome condensability into 3D genome organization [3].
[1] http://doi.org/10.1101/2024.12.22.629997