QCB Seminar featuring Taekjip Ha: Biophysical Principles of Genome Organization Across Multiple Scales
- Event Type
- Seminar/Symposium
- Sponsor
- Center for Quantitative Cell Biology
- Location
- Beckman Institute 3269 (third floor tower room)
- Virtual
- Join online
- Date
- May 15, 2025 11:00 am - 12:00 pm Central Daylight Time (U.S.)
- Views
- 84
- Originating Calendar
- QCB Event Calendar
Join us in Beckman 3269 and on Zoom for Taekjip Ha, Please note the change of day and time: this is a Thursday at 11 a.m.!
Title: Biophysical Principles of Genome Organization Across Multiple Scales
Abstract:
Recent advances in genetics, biochemistry, cell biology, and biophysics have contributed to our understanding that the genome is organized hierarchically, with higher-order macromolecular assemblies spanning spatial and temporal orders of magnitude. Beyond being wrapped around histones as irregular groups of “beads on a string”, chromatin is organized into topologically associated domains, which are composed of small and large loops, and form euchromatic and heterochromatic compartments. In this talk, I will present biophysical principles we are uncovering about genome organization across three different scales, including sequence-dependent DNA mechanics [1], chromatin loops for homology search [2], and polyamines' role in translating nucleosome condensability into 3D genome organization [3].
[1] http://doi.org/10.1101/2024.12.22.629997