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CANCELLED - Biological Physics (iPoLS) Seminar: Minjoung Kyoung (University of Maryland) "Functional regulation of 4D metabolic network between multienzyme glucosome condensates and mitochondria "

Event Type
Lecture
Sponsor
Physics Department
Location
3269 Beckman Institute (3rd floor tower room).
Date
Apr 21, 2023   2:00 pm  
Speaker
Minjoung Kyoung
Contact
Sharlene Denos
E-Mail
denos@illinois.edu
Phone
217-244-0672
Views
23
Originating Calendar
Physics - Biological Physics (iPoLS) Seminar

Glucose metabolism is biochemically intertwined between energy metabolism and building block biosynthesis in living cells. However, it has not been investigated yet how its metabolic network is orchestrated to govern glucose flux in space and time. We demonstrate that glucosome assemblies behave like liquid droplets in human cells and thus reversibly respond to environmental changes. In addition, we characterize a molecular architecture of the glucosome, which appears to be constructed from higher-ordered oligomeric structures of its scaffolder enzyme along with transient enzyme-enzyme interactions. Importantly, we reveal that enzymatic compositions of glucosomes are altered when they are spatially in proximity to mitochondria to functionally couple glycolysis with mitochondrial metabolism in human cells. Collectively, we propose that the subcellular localization-function relationship between glucosomes and mitochondria represents one of fundamental principles by which 4-dimensional metabolic networks are not only dynamically but also efficiently regulated in living human cells. 

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