Geospatial intelligence, which integrates remote sensing technology, geospatial analytics, and artificial intelligence, plays critical roles in developing solutions when deep domain science provides the foundations and knowledge. Here I will discuss our recent effort at the Agroecosystem Sustainability Center (ASC) at UIUC in applying geospatial intelligence to advance the scientific understanding and applications in food security, water security, and environmental sustainability, with a central focus on the US agriculture. These works developed at ASC increase our society's resilience and adaptability to maintain sustainability of ecosystem services food security and water resources under the influence of climate change and anthropogenic drivers.