A Novel Protein Complex System for Increased Immunogenicity and Functionality
Vaccine plays a key role in control of infectious diseases in human and animals. Several vaccines are commercially available. Recombinant vaccines have several advantages over killed and live attenuated vaccines, such as safety and production cost. One of my research interests is development of novel vaccine candidates against animal pathogens by engineering large protein complexes based on the homo-dimeric property of individual proteins. Through genetic fusion/linking two or three homo-dimeric protein genes, a large linear or network complex will be formed. This concept has been tested for different viruses including norovirus, hepatitis E virus, and astrovirus.