"Exercise and Extracellular Vesicles (ExerVs): Identification of the Molecular Basis for Health Benefits."
Exercise can initiate regenerative and remodeling processes that can preserve tissue structure and function across the lifespan. The mechanistic basis for exercise-mediated health benefits remains largely unknown. Recent studies demonstrate the ability for a variety of cell types to release extracellular vesicles (EVs) in response to exercise (ExerVs). These vesicles deliver a mixed cargo of regenerative peptides and noncoding RNAs that mediate tissue crosstalk and facilitate health benefits. In this seminar, speakers will share novel findings that demonstrate the ability for exercise and disuse to regulate quantity and content of circulating EVs. The cellular origin of ExerVs will also be examined. Finally, the involvement of ExerVs in mediating skeletal muscle regenerative and remodeling processes will be discussed.