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BIOE 500 Seminar - Dr. Juhi Samal

Event Type
Department of Bioengineering
2310 Everitt Laboratory
Mar 2, 2023   11:30 am   12:20 pm

Tuning the Sugar Symphony: Modulation of Tissue Glycosylation in Central

Nervous System Disorders using Biomaterials

Most biological functions in the central nervous system occur through glycosylated

proteins and lipids, and alteration in glycosylation alters the structure and function of the

glycoproteins. This underlines the significance of glycans in both disease pathophysiology

and therapy. Defects in glycosylation are associated with several diseases and

abnormalities of the nervous system. However, the complexity of the nervous system,

intricacy of glycosylation, and limitations of the glyco-analytical platforms impede the

holistic investigation of glycan modulation in disease pathophysiology. To this end, this

talk will focus on the modulation of tissue glycome with aging, acute, and chronic CNS

disorders, and their modulation with biomaterial therapies. The talk will also cover the

application of multimodal glycan analysis platform for elaborate spatial analysis of tissue

glycans. Given the importance of glycosylation in biological interactions and function,

future biomaterial-based, glycan-targeted therapies can be designed to promote proregenerative

response in CNS disorders.

Juhi Samal is a postdoctoral researcher at the Segura Lab (

in the department of Biomedical Engineering at Duke University. Her research focusses

on the development of biomaterial-based interventions for central nervous system (CNS)

disorders with a special focus on tissue glycosylation in the CNS. Her research interests

are exploring the modulation of tissue glycosylation in acute and chronic CNS disorders

and developing biomaterial therapies to tune the glycan signature towards a proregenerative

response. She is recipient of numerous awards, including the Regeneration

Next Initiative postdoctoral fellowship, Julia Polak Award European Doctorate Award,

DAAD (Deutscher Akademischer Austauschdienst) Fellowship, and she has received

several awards for research dissemination and excellence at different conferences, at

both national and international levels. Juhi received her PhD from CÚRAM, National

University of Ireland Galway, where she was awarded Hardiman Fellowship for

conducting her doctoral research. Prior to that, she received her Bachelor’s (B.Tech)

degree in Biotechnology and her Master’s (M.Tech) in Biotechnology and Biochemical

Engineering from the Indian Institute of Technology (IIT), Kharagpur, India.

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