The study of dynamic nuclear processes is at the heart of understanding physical phenomena at scales spanning the minute interactions between quantum many-body systems to the massive mergers of neutron stars. Even restricting one's view to a single reaction between two well-defined collision partners, it is clear that there exists a complex interplay between transfer, collective excitations, dissipative effects, etc. To address these disparate effects and phenomena a comparably robust microscopic approach, time-dependent density functional theory (TDDFT), has been used to study the real-time evolution of nuclear systems. I will highlight recent advances and ongoing work in the description of the dynamics of low-energy nuclear reactions for a variety of systems across the chart of nuclides. Testing and expanding the limits of our theoretical understanding of how nuclei interact is more important than ever as our ability to explore exotic nuclear reactions with unstable partners is poised to expand greatly as we enter the FRIB era, further probing and eroding the terra incognita of the nuclear landscape.