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Fluorescent imaging advances for the study of osteocyte mechanotransduction mechanisms

Event Type
Mechanical Science and Engineering
4100 Sidney Lu Mechanical Engineering Building
Apr 2, 2024   4:00 pm  
Dr. Karl Lewis, Meinig School of Biomedical Engineering, Cornell University
Amy Rumsey


Prof. Lewis and his group work to better understand the interplay of mechanical inputs and biological outcomes in bone. In service of this goal, they develop novel intravital imaging techniques for studying osteocyte mechanotransduction and mechanobiology in vivo. These approaches leverage fluorescent signal to observe cellular/molecular level events and allow for experiments that keep critical endocrine and tissue crosstalk pathways intact. As such, they offer powerful insights into cellular behavior in health and disease. In this presentation, Prof. Lewis will share new approaches and subsequent findings related to osteocyte mechanoregulation and endocytosis.

 About the Speaker

Dr. Karl Lewis is an assistant professor in the Meinig School of Biomedical Engineering at Cornell University. Prior to starting his lab at Cornell, he completed his PhD training with Prof. Mitch Schaffler at The City College of New York, and a post-doctoral fellowship with Prof. Alex Robling at the Indiana University School of Medicine. The Lewis Lab is  working on 3 main focus areas; namely investigation of bone mechanobiology, expanding non-linear microscopy approaches in bone tissue, and establishing the use of novel fluorescent probes for imaging cellular dynamics in vivo.

Hosts: Professor Mariana Kersh and Professor Iwona Jasiuk 

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