Translation produces proteins that are the major determinants of cellular functions. Regulation of translation is an essential part of the control of gene expression: it not only provides a critical and fine-tuned control in gene expression, but also offers the cell an opportunity to rapidly respond to internal cellular cues and external stimuli without invoking nuclear events. Professor Jin and her lab focuse on understanding the molecular mechanisms of translation and translational regulation in the cell. They are best known for revealing structures and functions of the ribosome, as well as RNAs and RNA-binding proteins involved in the cellular translation process that is fundamental to gene expression and regulation. Several principal research avenues have evolved ranging from exploring functions of the 5’-untranslated region (5’UTR), RNA-binding protein and ribosomal RNA modification in translation initiation to understanding the molecular mechanisms of co-translational quality control. Professor Jin's lab is uniquely positioned to investigate these fundamental questions, and look forward to the challenges and opportunities that confront these investigations.
Speaker: Hong Jin | Dept. of Biochemistry, CAS Fellow 2018-19