A remarkable feature of modern integrated circuit technology is its ability to operate in a stable fashion, with almost perfect reliability, without physical or chemical change. Recently developed classes of electronic materials create an opportunity to engineer the opposite outcome, in the form of ‘transient’ devices that dissolve, disintegrate or otherwise disappear at triggered times or with controlled rates. Water-soluble transient electronics serve as the foundations for interesting applications in bioresorbable medical implants based on body chemistry. In my talk, I will present the foundational concepts in chemistry, materials science, and assembly processes of bioresorbable medical devices. Wireless electronic stimulators designed for use in treatment of temporary bradycardia provide application example.