Changes in the number of Weyl nodes in Weyl semimetals occur through merging processes, usually involving a pair of oppositely charged nodes. More complicated processes involving multiple Weyl nodes are also possible, but they typically require fine tuning and are thus less stable. In this work, we study how symmetries affect the allowed merging processes and their stability, focusing on the combination of a two-fold rotation and time-reversal (C2T) symmetry. We find that, counter-intuitively, processes involving a merging of three nodes are more generic than processes involving only two nodes. Our work suggests that multi-Weyl-merging may be observed in a large variety of quantum materials, and we discuss SrSi2 and bilayer graphene as potential candidates.