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Professor Markus Covert, Stanford University, "Whole-cell modeling of E. coli: from simulation to discovery"

Event Type
Quantitative Cell Biology STC
Beckman 3269
Mar 4, 2024   3:00 pm  
Lisa Johnson
Originating Calendar
Chemistry - Physical Chemistry Seminars

Abstract: Francis Crick first called for a coordinated worldwide scientific effort to determine a “complete solution” of the bacterium Escherichia coli. We have been working for some years now to complete a model of E. coli that takes into account all of the known functions of every well-annotated gene, in order to better understand and predict the behavior of this scientifically-relevant and industrially-significant model organism. I will discuss our ongoing efforts to improve this model, most recently with new modeling added to better describe growth rate control, transcription unit architecture and tRNA metabolism. I will then highlight our newest “whole-colony” models, a multi-scale modeling effort in which every individual within a simulated colony is running the latest version of the whole-cell model, to calculate population-level emergent behaviors based on molecular interactions and events as the colony responds to the sudden introduction of antibiotics.

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