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Dr. Houhui Xia, University of Rochester Medical Center, "Reversible protein phosphorylation in synaptic dysfunction and Neurodevelopmental disorders"

Event Type
MIP Seminar Committee
Charles Miller Auditorium, B102, CLSL
Sep 21, 2023   11:00 am  
Houhui Xia, M.Sc., Ph.D.
Julie Moore
Originating Calendar
Molecular and Integrative Physiology (MIP) Department Seminar Series
"Reversible protein phosphorylation in synaptic dysfunction and Neurodevelopmental disorders"

Dr.Xia's research focus' on the signaling roles of protein phosphatase-1 (PP1), mainly focused on its inhibitors (inhibitor-1 and inhibitor-2 (I-2)) and targeting proteins (neurabin, spinophilin, HDAC family molecules and nuclear inhibitor of PP1 (NIPP1)), in synaptic transmission, plasticity, CREB mediated gene transcription and aforementioned brain functions. We used a variety of techniques, including confocal immuno-fluorescence, immuno-gold electron micrograph (EM), biochemistry (including IP, western blotting), viral mediated gene transfer (including lenti-virus mediated knocking down genes of interest and then replacing it with recombinant proteins---molecular replacement), FRET/BRET imaging, transgenic/knockout mice (I-2, NIPP1 and PP1), cellular electrophysiology and behavioral testing. We use primary hippocampal/cortical cultures, acute slices and knockout mice for our proposed studies. 

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