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Title: "Interneuron hypofunction in Fragile X Syndrome"
Current ResearchA symptom to circuit approach to understand autism- How are cortical circuits assembled during typical brain development?- What are the underlying circuit defects in autism and intellectual disability?- What are the best ways to model neuropsychiatric symptoms?We are trying to answer these questions using the latest state of the art tools in neuroscience research, such as in vivo 2-photon calcium imaging and silicon probes to record network activity, chemogenetics with DREADDs or optogenetics to manipulate neuronal activity, and sophisticated behavioral tasks.
https://porteralab.dgsom.ucla.edu/pages/people