Depressive disorders are common, particularly among those who are unemployed, uninsured, and have less education and income. This population is also more likely to hold stigmatizing beliefs and negative attitudes toward conventional mental health treatment and less likely to receive services. Mindfulness-based interventions have collectively been shown to improve psychological outcomes. Mindfulness-based interventions for depression delivered within a community health center setting may be more acceptable and accessible for traditionally underserved populations. This study presents data from a mindfulness-based intervention for depression delivered to African American women in a Federally Qualified Health Center (FQHC) in Chicago. This study provides strong early evidence for a generalizable model for delivery of streamlined mental health interventions in a community-based setting that will be scalable to wider populations, closing the gap on disparities in mental health service utilization.