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Statistics Seminar - Shulei Wang (University of Illinois Urbana Champaign)

Event Type
Department of Statistics
Sep 16, 2021   3:30 - 4:30 pm  
Originating Calendar
Department of Statistics Event Calendar

Title: Robust Differential Abundance Test in Compositional Data

Abstract: Differential abundance tests in compositional data are essential and fundamental tasks in various biomedical applications, such as single-cell, bulk RNA-seq, and microbiome data analysis. However, despite the recent developments in these fields, differential abundance analysis in compositional data remains a complicated and unsolved statistical problem, because of the compositional constraint and prevalent zero counts in the dataset. This study introduces a new differential abundance test, the robust differential abundance (RDB) test, to address these challenges. Compared with existing methods, the RDB test 1) is simple and computationally efficient, 2) is robust to prevalent zero counts in compositional datasets, 3) can take the data’s compositional nature into account, and 4) has a theoretical guarantee of controlling false discoveries in a general setting. Furthermore, in the presence of observed covariates, the RDB test can work with the covariate balancing techniques to remove the potential confounding effects and draw reliable conclusions.


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Meeting ID: 815 7970 4788
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