STC for Quantitative Cell Biology Seminar: Markus Covert
- Event Type
- Lecture
- Sponsor
- STC for Quantitative Cell Biology Seminar Series
- Location
- Beckman Institute Room 3269 (3rd floor tower room)
- Virtual
- Join online
- Date
- Mar 4, 2024 3:00 pm
- Speaker
- Markus Covert, Stanford University
- Contact
- Lisa Johnson
- lisa3@illinois.edu
- Views
- 245
- Originating Calendar
- Beckman Institute Calendar (internal events only)
Markus Covert, Stanford University, will lecture on "Whole-cell modeling of E. coli: from simulation to discovery"
Abstract: Francis Crick first called for a coordinated worldwide scientific effort to determine a “complete solution” of the bacterium Escherichia coli. We have been working for some years now to complete a model of E. coli that takes into account all of the known functions of every well-annotated gene, in order to better understand and predict the behavior of this scientifically-relevant and industrially-significant model organism. I will discuss our ongoing efforts to improve this model, most recently with new modeling added to better describe growth rate control, transcription unit architecture and tRNA metabolism. I will then highlight our newest “whole-colony” models, a multi-scale modeling effort in which every individual within a simulated colony is running the latest version of the whole-cell model, to calculate population-level emergent behaviors based on molecular interactions and events as the colony responds to the sudden introduction of antibiotics.