“Therapeutic biomaterials: Engineering material “Structure” to modulate biologic delivery”
The ability to deliver therapeutics within and across biologic barriers is a much sought-after goal. In this talk, I will discuss our recent work in developing nanostructured materials for biologic delivery as well as injectable micro/nanoscale materials for the modulation of fibrosis and immune activation. By incorporating micro and nanoscale features into biomaterials, one can modulate properties such as tissue permeability, matrix production, and cell activation. The understanding of how small-scale topographies can influence the biological microenvironment allows us to design platforms for applications in therapeutic delivery and tissue regeneration. Micro and nanostructured materials can add functionality to current drug delivery platforms while becoming an enabling technology leading to new basic discoveries in the pharmaceutical and biological sciences.