UIUC Biophysics and Related Seminars

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CHBE 565 Seminar, Prof. Yvonne Chen, University of California, Los Angeles, "Engineering Next-Generation T Cells for Cancer Immunotherapy" (host: Prof. Huimin Zhao)

Event Type
Seminar/Symposium
Sponsor
Chemical & Biomolecular Engineering and International Paper Company
Location
https://illinois.zoom.us/j/85172746102?pwd=NTBFeWJiTWdLNUJybGlEZ2tNMFZBUT09&from=addon
Virtual
Date
Feb 23, 2021   2:00 pm  
Contact
Christy Bowser
E-Mail
cbowser@illinois.edu
Phone
217-244-9214
Views
2
Originating Calendar
Chemical & Biomolecular Engineering Seminars and Events

The adoptive transfer of T cells expressing chimeric antigen receptors (CARs) has demonstrated clinical efficacy in the treatment of advanced cancers, with anti-CD19 CAR-T cells achieving up to 90% complete remission among patients with relapsed B-cell malignancies. However, challenges such as antigen escape and immunosuppression limit the long-term efficacy of adoptive T-cell therapy. Here, I will discuss the development of and clinical data on next-generation T cells that can target multiple cancer antigens and resist antigen escape. I will also present recent work on tuning CAR signaling activities via rational protein design to achieve greater in vivo anti-tumor efficacy. This presentation will highlight the potential of synthetic biology in generating novel mammalian cell systems with multifunctional outputs for therapeutic applications.

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