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Human decision processes across multiple scales of organization affect changes in land use and land cover (LULC) at multiple scales. These LULC changes, in turn, have implications for ecosystem and human well-being. Efforts to both understand the role of human action within the Earth system and evaluate interventions that aim to improve environmental and social outcomes are aided by coupled social-environmental modeling. This presentation describes the contributions, potential, and challenges of spatial agent-based models in contributing to the science and management of the Earth system at multiple scales, and the opportunities and challenges associated with their inherent complexity and integration with spatial data.