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Biochemistry / Biophysics Seminar of Special Interest: Dr. Catherine Royer (Rensselaer Polytechnic Institute) "Quantitative mapping of proteins in live cells using advanced microscopy"

Event Type
Seminar/Symposium
Topics
academic, biochemistry
Sponsor
Dr. Emad Tajkhorshid
Location
Charles G. Miller Auditorium (B102 CLSL)
Date
Apr 26, 2019   12:00 pm  
Speaker
Dr. Catherine Royer
Cost
Free
Contact
Sherry Unkraut
E-Mail
sunkraut@illinois.edu
Phone
217-333-2013
Views
106
Originating Calendar
Biochemistry Department Seminars

Cells modulate their metabolism, growth and proliferation in response to external stimulii. We use advanced fluorescence microscopy methods to characterize, in live cells, the proteins implicated in environmental regulation of cellular expression programs and cell state transitions. The approaches we use include scanning fluctuation microscopy, fluorescence lifetime imaging/phasor and single molecule localizaiton super-resolution microscopy. With these tools we have investigated the the role of biological noise in the transcriptional switch between glycolysis and gluconeogenesis in B. subtilis, regulation of the balance between growth and division in budding yeast and its control by nutrients, the molecular basis for the pressure-induced SOS response in E. coli and the stoichiometry of postsynaptic density complexes and glutamate receptors in live neurons. In each case our studies revealed fundamental molecular mechanisms responsible for the regulation of important biological functions.

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