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"Lymphatic-Glymphatic Roles in Alzheimer’s Disease," by Jonathan Kipnis, PhD, BJC Investigator, Alan A. and Edith L. Wolff Distinguished Professor of Pathology and Immunology ,Professor of Neurology, Neuroscience and Neurosurgery, Washington University School of Medicine

Event Type
Seminar/Symposium
Sponsor
Neuroscience Program
Location
Zoom - Click that day on "Register" below to enter event
Virtual
Date
Sep 15, 2020   4:00 pm  
Speaker
Jonathan "Jony" Kipnis, Washington University School of Medicine
Registration
Registration
Contact
Paul Bonthuis
E-Mail
bonthuis@illinois.edu
Views
44
Originating Calendar
Neuroscience Program Seminars

Immune cells and their derived molecules have major impact on brain function. Our results demonstrate that meningeal space, surrounding the brain, is the site where CNS-associated immune activity takes place. We discovered a presence of meningeal lymphatic vessels that drain CNS molecules and immune cells to the deep cervical lymph nodes and also regulate perfusion of the brain by CSF (glymphatic flow). This communication between the CNS and meninges is playing a key role in several neurological, primarily in Alzheimer’s disease. Interestingly, the integrity of meningeal lymphatics also dictates the response to immunotherapy in AD. Meningeal lymphatics, overall, may serve as a novel therapeutic target for neurological disorders.

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