11 matches found
I will describe the engineering of molecular tools to read and write neuronal function with light, with the goal of investigating how neuronal circuits function and adapt in the context of the living brain.
KCNQ2/3 channels have arisen as critical regulators of neonatal brain excitability. Highlighting the importance of these channels, a growing number of loss- and gain-of-function variants in Kcnq2/3 have been reported in patients with severe neonatal epileptic encephalopathy. In this seminar, we will discuss our recent progress in deciphering the function of KCNQ2/3 channel
AKT is a central kinase implicated by genetics in neurological disorders and diseases, such as Alzheimer’s disease, schizophrenia, and glioblastoma. AKT also regulates numerous intracellular signaling pathways affecting a myriad of neuronal processes, such as protein synthesis dependent synaptic plasticity. Importantly, it is expressed in the brain as three distinct isofor
Dr. Golshani has built new open-source miniaturized microscopes for imaging network dynamics in freely behaving mice. He is using these tools to image how hippocampal place cell ensembles become unstable in models of epilepsy.
Learning to fear threats in the environment is critical for survival, but often leads to mental illnesses including PTSD. Once learned, traumatic memories can be suppressed—though this is often short-lived. New work reveals how brain circuits that make and break traumatic memories function to regulate fear and its relapse.
Synaptic plasticity underlies circuit refinement and memory formation. The NMDA-type glutamate receptor plays a central role in this process. I will discuss its function, trafficking, and a novel mechanism of regulation via Wnt signaling.
The brain is fueled by nutrition; individual needs for nutrients are, in part, based on genetics. Dr. Cheatham will present data from an infant electrophysiology study that will illustrate two points: maternal genetics are an important consideration in infant brain development, and nutrients work synergistically to support brain function.
Sensory feedback from the body influences the activity of brain circuits that organize motivated behavior and affective state. We use rodent models to study central neural pathways through which gastrointestinal signals shape stress responsiveness and aversively-motivated avoidance behaviors.
Recombinant viruses such as adeno-associated viruses have become major tools in the development of gene therapy for correcting genetic disorders. This seminar will highlight such work on the neurodevelopmental disorder, Fragile X Syndrome.
It is becoming increasing apparent that the abuse of alcohol during adolescence has long lasting effects of brain and behavior in adulthood. Our studies in a rodent model of intermittent adolescent alcohol exposure to investigate have revealed these changes include alterations in the prefrontal cortex.
"Neurobiological Investigation of Vocal Production Learning in the Mammalian Brain" by Michael Yartsev, Ph.D., Assistant Professor of Neurobiology and Engineering New York Stem Cell Foundation - Robertson Investigator Helen Wills Institute of Neuroscience Graduate Program UC Berkeley-UCSF Graduate Program in Bioengineering University of California at Berkeley
Learning a language is generally considered the crown jewel of human abilities. Yet the core question of ‘What is it about the human mammalian brain that allows us to learn our language?’, remains unresolved. In humans, language acquisition is mediated by a process called ‘vocal learning’. While humans are expert vocal learners, a remarkably sparse subset of mammals share