Indonesian Students Club

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TCB Group "Clamps and clamp loaders in the archaeal/eukaryotic lineage"

Event Type
Seminar/Symposium
Sponsor
Klaus Schulten - TCB Group
Location
BI - 3269
Date
Nov 11, 2013   3:00 - 4:00 pm  
Speaker
Prof. Isaac K.O. Cann, UIUC - Microbiology and Animal Sciences
Contact
Donna H. Fackler
E-Mail
dhfackler@ks.uiuc.edu
Phone
300.8022
Views
2218
Originating Calendar
Beckman Main Calendar

Life on our planet can be divided into three domains: the Archaea, Eukarya and Bacteria. In all three domains of life, the speed required for DNA synthesis is only possible because of the evolution of a donut shaped protein that interacts with a replicative DNA polymerase to duplicate the genome in a processive manner. The donut-shaped proteins are loaded by a heteropentameric protein complex that harnesses energy through hydrolysis of ATP bound at its interfaces. In this presentation, I will discuss the evolution of the clamp loader in the archaeal/eukaryotic sister lineages, and provide evidence for an alternative mechanism for loading the Methanosarcina acetivorans clamp loader, an intermediate between the commonest clamp loader in the archaea and the very complex forms found in eukaryotic organisms. I will further discuss our attempt to use these processive factors to test Woese’s hypothesis of the existence of a Darwinian threshold.

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