Seminars of Interest

Back to Listing

POSTPONED - Biochemistry Seminar: Dr. Christopher Ahern (University of Iowa), "The Power of Small: Atomic Mutagenesis in a Post-Structural Era"

Event Type
Seminar/Symposium
Topics
academic, biochemistry
Sponsor
Dr. Emad Tajkhorshid
Location
Charles G. Miller Auditorium (B102 CLSL)
Date
Jan 26, 2018   12:00 pm  
Speaker
Dr. Christopher Ahern
Cost
Free
Contact
Sherry Unkraut
E-Mail
sunkraut@illinois.edu
Phone
217-333-2013
Views
77
Originating Calendar
Biochemistry Department Seminars

THE SEMINAR WILL BE RESCHEDULED FOR LATER THIS SEMESTER.

The Ahern laboratory has a long-standing interest in the pharmacology and function of the voltage-gated ion channels that support electrical signaling in muscle and nerve cells. My laboratory uses chemical biology, protein engineering and biophysics to quantify membrane protein function at high resolution.  Our use of genetic code expansion and the design, synthesis and encoding of unnatural amino acids to rescue ion channel genes harboring nonsense (stop) codons, has yielded several interesting recent discoveries: atomic and subatomic details of the function of ion-channel voltage sensors; new protein-chemical interactions relevant for potassium channel gating; H-bond networks that act as molecular timers in potassium channels; and novel mechanisms of drug interactions with ion channels.  Data will be discussed related to the role of cation-pi interactions between sodium channel aromatic residues and toxins or therapeutics, and in context of protein structure. Further, data are provided for a mechanistic basis for a therapeutic potassium channel opener.

link for robots only