"A Framework to Engineer Nanoparticle Delivery Systems for In Vivo Targeting"
The delivery of medical agents to a specific diseased tissue or cell is critical for diagnosing and treating patients. Nanomaterials are promising vehicles to transport agents that include drugs, contrast agents, immunotherapies and gene editors. They can be engineered to have different physical and chemical properties that influence their interactions with their biological environments and delivery destinations. In this presentation, I will introduce current design of nanoparticle delivery systems and how the biology of disease should inform their design. I will also use case studies using nanoparticle delivery to solid tumour to illustrate the importance of pathophysiology in mediating the delivery process. Finally, I will introduce a new framework for building optimal delivery systems that uses nanoparticle–biological interaction data, machine learning and computational analyses to guide future nanomaterial designs and delivery strategies.
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About the Speaker
Dr. Chan is currently the Canadian Research Chair in Nanoengineering in the Institute of Biomaterials and Biomedical Engineering at the University of Toronto. He is also the Head of Biomedical Engineering. Dr. Chan received his B.S. degree from the University of Illinois in 1996, Ph.D. degree from Indiana University in 2001, and post-doctoral training at the University of California (San Diego). He moved to Toronto in 2002 to lead the Integrated Nanotechnology/Biomedical Sciences Laboratory. His research interest is in the development and translation of nanotechnology for diagnosing and treating cancer and infectious diseases. He has received NSERC E. W. R. Memorial Steacie Fellowship, Kabiller Young Investigator Award in Nanomedicine, the BF Goodrich Young Inventors Award, Lord Rank Prize Fund award in Optoelectronics (England), and Dennis Gabor Award (Hungary). He is currently an Associate Editor of ACS Nano. Finally, he is also affiliated with a number of different departments at the University of Toronto: Department of Materials Science and Engineering, the Terrence Donnelly Center for Cellular and Biomolecular Research Chemistry, Chemistry and Chemical Engineering.
