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ISE Seminar-Optimization Models for Cancer Treatment Using Arc Therapy

Event Type
Industrial & Enterprise Systems Engineering
303 Transportation Bldg
Mar 10, 2014   4:00 pm  
Dr. David Papp, Harvard Medical School/Massachusetts General Hospital
Holly Kizer
Originating Calendar
ISE Seminar Calendar


During radiotherapy, cancer patients are irradiated with beams of ionizing radiation that kill both cancerous and healthy cells. Treatment, therefore, has to be carefully designed in order to deliver the prescribed radiation dose to the tumor while sparing critical organs and healthy tissue from damage. Recently, radiotherapy delivery using arc therapy has been gaining popularity in clinics, since it has the potential to improve treatment plan quality while shortening treatment time. During this type of therapy, patients can be irradiated from virtually every angle, with a beam whose shape is continuously changing as the radiation source revolves around the patient. Optimizing such a treatment is much more challenging than designing conventional treatments, because natural formulations of this problem are both large-scale and non-convex optimization models. As a result, currently there is little support of this modality in treatment planning software, and the solutions are based on rather weak heuristics. The talk will present a novel optimization model that can be solved approximately using convex optimization methods, and can also be used in multi-criteria treatment planning. Computational results show that the approach provides high quality treatment plans for a variety of treatment sites.


Dr. Papp has received his PhD in Operations research from Rutgers University in 2011, for his dissertation on polynomial programming methods for statistical estimation problems. He currently holds a joint appointment with Harvard Medical School and Massachusetts General Hospital. Prior to joining HMS, he was a postdoctoral fellow at the Department of Industrial Engineering and Management Sciences at Northwestern University. His primary interest is in computational optimization; his research involves developing deterministic and stochastic optimization approaches to solve problems in healthcare, statistics, and engineering.


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