Our lab is focused on answering two major questions. (1) What are the critical metabolic regulators of cancer growth and metastasis? and (2) What is the role of tumor microenvironment in modulating cancer cell metabolism? Several recent studies have identified multi-faceted role of tumor microenvironment in regulating cancer cells’ growth, metastasis and drug resistant. Treating cancer as an isolated epithelial cell disease has not been successful because of the unique interplay between the various aspects of the tumor and microenvironment. Thus, the microenvironment has been the recent target of molecular strategies for tumor treatment. However, little is known about its role in modulating cancer cell metabolism. Current studies in our lab are focused on identifying the role of stromal cells in regulating cancer cell metabolism via metabolites and secreted exosomes. We recently have demonstrated a novel role for exosomes within the tumor microenvironment in regulating the metabolic adaptation observed in cancer cells, and uncovered the underlying mechanism of this regulation. Further, in a separate study we demonstrated that altered reactive stromal metabolism is the driver for regulating cancer growth in its harsh microenvironment and targeting this aberration could create metabolic vulnerability in cancer cells by disrupting the metabolic crosstalk between stromal and cancer cells. Our study revealed the fundamental metabolic differences between cancer associated stromal cells and normal stromal cells, which support tumor growth and progression. Our work underscores the reliance of cancer cells on stromal cells, presenting an opportunity to target tumor stroma and cancer cells simultaneously to improve therapeutic outcomes.