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Biochemistry Seminar: Dr. Christopher Brett (Concordia University), "The ILF Pathway: Master Controller of Lysosomal Transporter Protein Lifetimes "

Event Type
Dr. Rudy Fratti
Charles G. Miller Auditorium (B102 CLSL)
Nov 3, 2017   12:00 pm  
Dr. Christopher Brett
Sherry Unkraut
Originating Calendar
Biochemistry Department Seminars

Everyone recycles for health and longevity – at least from the perspective cell biologists. This is because all eukaryotic cells, including the trillions that constitute you and I, rely on organelles called lysosomes to recycle biomaterials. This activity provides cells with nutrients upon starvation and clears toxic biomaterials that accumulate with age. Underlying these functions are specialized proteins within their membrane that mobilize nutrients and control cell aging and metabolic programs. Defects in these transporter proteins are associated with metabolic and age-related disorders, such as cancers and Alzheimer’s disease. Despite their importance, we know little about lysosomal transporter proteins lifetimes or how they are regulated. Until recently, when my group discovered a new process in S. cerevisiae called the IntraLumenal Fragment (ILF) pathway: In response to misfolding, substrate levels or Target Of Rapamycin (TOR) signaling, lysosomal transporter proteins are sorted into an area of membrane between docked organelles that is internalized within the lumen and degraded upon membrane fusion. Using cell-free assays, tractable genetics, quantitative morphometrics and live cell microscopy, we have begun to uncover the molecular basis of this fundamental cellular process and its role in metabolism, aging and cell death. As the underlying machinery is evolutionarily conserved, we speculate that the ILF pathway plays an important role in human cell aging and metabolism.

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